It happened around 8:30 p.m. Tuesday near Broadway and Mount Vernon Street.
Both officers were taken to the hospital for treatment.
Police said 10-25 rounds were fired before the suspect fled possibly in a white van.
The officers were sitting at a red light when the suspect allegedly fired shots into the unmarked vehicle.
One officer managed to exchange fire with the suspect. It's not clear if that person was hit.
Authorities said a male detective was shot twice in the arm.
A female detective was shot in the hand.
Their injuries are considered non-life threatening.