The investigation is underway along the 200 block of Nelson Street near Pekoe Avenue.
Durham police say the victims' injuries were non-life-threatening. The identities of those injured have not been released at this time.
Officials have not disclosed if there is a suspect in custody at this time.
Anyone with information on the shooting is asked to contact the Durham Police Department at (919) 560-4440 ext. 29336 or CrimeStoppers at (919) 683-1200.
See breaking news? Tell us about it here.
This is a developing story, stay with ABC11 for more updates.