The wreck happened around 6:30 a.m. Saturday morning.
Police said the 29-year-old driver, who has been identified as David Robinson, of Durham, overcorrected, crossed the center line and then ran off the left side of the roadway.
The van then hit a ditch and flipped.
Robinson was ejected and pronounced dead at the scene.
Police say he was not wearing a seatbelt at the time of the crash.
There were no other vehicles involved.