Sheriff Charles Blackwood said Alamance deputies were chasing a man wanted in connection with a Graham drive-by shooting.
Deputies tried to pull him over, couldn't and pursued him on Highway 54 into Orange County.
When the chase got to near Carrboro, Alamance deputies used a pit maneuver to spin the suspect's car out. One Alamance County deputy's car T-boned the car.
The driver jumped from the car as deputies arrested a female passenger. The deputies and the woman were not injured.
Law enforcement officers are out with K-9 units looking for the driver who ran from the scene.
See breaking news? Tell us about it here.