Mebane Police called for assistance around 11 p.m. Saturday after the suspect reportedly broke into a home on Virginia Lee Lane and assaulted the two occupants.
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Authorities said the suspect, Keo Crockett, was armed and had fired the gun during the invasion.
Deputies knocked on the front door and Crockett exited holding a gun, which he reportedly raised and pointed at the deputies.
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The deputies fired shots, killing Crockett.
Orange County Sheriff Charles Blackwood responded, notified District Attorney James Woodall of the incident and called the State Bureau of Investigations to investigate. The deputies involved have been placed on administrative leave, as is standard procedure in instances such as this.
"We want to say that our thoughts and prayers are with the decedent's family and friends," the Orange County Sheriff's Office said in a statement. "The loss of human life under circumstances such as this is tragic and leaves us all asking why."