The incident happened around 2:30 a.m. on Western Boulevard near Chaney Road.
The driver told ABC11's Ana Rivera he was leaving work when the person ran out in front of his car.
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He said the man darted across the road to Cook Out "like a deer" giving him "no time to react."
The driver said he jumped out of the car, realized the man still had a pulse and called 911.
He said the man was still breathing when he was taken away to the hospital.
Police said the man has serious injuries but is expected to be OK.