Northbound lanes of MLK Jr. Freeway were closed at the Bragg Boulevard exit while police investigated what they called a "critical injury" traffic crash.
It happened shortly after 2:30 p.m. The freeway reopened at 4:14 p.m., police said.
The pedestrian was identified as Jonathan S. Sloan, 40. He was taken to Cape Fear Valley Medical Center, where he died from his injuries.
The driver of the vehicle has been identified as Adrianna E. Galloway, 23, of Fayetteville. Galloway was driving a 2004 Ford Explorer.
No charges have been filed but the incident remains under investigation.
Anyone with information regarding the traffic crash is asked to contact Officers with the Fayetteville Police Department's Traffic Unit at (910) 433-1807 or Crimestoppers at (910) 483-TIPS (8477). Crimestoppers information can also be submitted electronically, by visiting http://fay-nccrimestoppers.org and completing the anonymous online tip sheet, or by downloading the FREE "P3 Tips" app available for Apple devices in the Apple App Store and available for Android devices in Google Play.