It happened at the Holiday Inn Express at 150 Collins Cross Road.
A suspect was taken into custody.
Holly Springs Police said EMS treated the victim, who was described as conscious and alert and was later taken to a hospital for further treatment.
Police initially said the two people involved knew each other but later determined that they did not.
There is no ongoing threat to the public, HSPD added. The motive for the stabbing remains unclear.
An ABC11 crew is working to gather more information.
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