Officers responded around 3:02 p.m. to the 9400 block of Glenwood Avenue near Lumley Road after receiving reports of a crash. Police said two vehicles were involved in the collision.
Four people were taken to the hospital. Authorities said two of the victims suffered injuries believed to be life-threatening. The other two victims, including a juvenile, suffered injuries that appeared to be non-life-threatening.
Investigators have not yet determined what caused the crash.
The investigation remains ongoing, and traffic in the area is being affected as crews work at the scene.
Police said additional information will be released as it becomes available.