It is part of the long-term plans for an improvement project.
The ramp closure will last for three months and will not reopen until the end of August.
Traffic will be detoured from Hillsborough Street onto Blue Ridge Road, Wade Avenue east and then back to 440 east.
The improvements are supposed to help traffic flow and access to the beltline.
It will also help with traffic congestion and the bottleneck that happens when moving from four to six lanes.
The entire project should be complete by 2025.