According to authorities, the crash was reported around 9:40 a.m. eastbound at mile marker 441, near N.C. 39. This is about four miles south of Bunn.
A Ford Expedition was headed eastbound when a rear tire blew out, North Carolina State Highway Patrol said. The vehicle, which had two adults and five children inside, then hit a guardrail and flipped.
The driver of the SUV was traveling at the 70-mph speed limit.
Two girls, ages 10 and younger than 16 were ejected from the SUV. NCSHP said both were not wearing seatbelts.
The 10-year-old sustained serious injuries and was airlifted to WakeMed in Raleigh.
The others involved in the crash were also injured but are expected to recover.