The children collected toys and handmade hats and they'll be delivered by Santa to kids at Duke Children's Hospital on Christmas Eve.
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Both children who made donations are winning their own battles with cancer.
Ten year-old Zach Schwab and his family collected toys year round and are making stops at multiple hospitals as part of their organization called Zach's Toy Chest.
Thirteen year-old Ryan Thompson and her grandmother crocheted hats by hand all year and have a team of friends across the nation helping them, as part of Ryan's Hats of Hope for Little Warriors.
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Both children faced a fight for their lives just a few months or a few years old, now they're giving back to those who're in the middle of their own cancer battle.
"The children who survive have a special responsibility never to forget the community that they were a part of," Ryan's grandmother," Helen McNeill said, "and to always be that face of hope that a child can make it through this kind of disease."