The company, which makes routers, switches and software, made the announcement during a conference call discussing its fiscal fourth-quarter earnings.
There's no word whether the layoffs will impact cisco workers in RTP.
Earlier this year, Gov. Pat McCrory announced Cisco was bringing 550 new jobs to RTP by the year 2017.
The San Jose, California-based company reported a 1 percent decline in profit, to $2.25 billion, for the latest quarter.
The company estimates pretax charges of up to $700 million, with about $250 to $350 million recorded in the current quarter, for the restructuring.
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