It happened just before midnight in Cumberland County at I-95 Business/US Highway 301 and Elk Road intersection.
Upon arrival, first responders found a motorcycle and the rider lying in the roadway.
Our ABC11 crew on the scene said, however, that the 'reported' motorcycle looked like a dirt bike.
The motorcyclist was taken to Cape Fear Valley Hospital with life-threatening injuries. They have not been identified.
No further details have been released.
All southbound lanes of I-95 Business/US Hwy 301 were closed temporarily afterward.
North Carolina Highway State Patrol is conducting an investigation.