Officers responded at 2:45 p.m. to University Drive and Larchmont Road.
DPD said Daniel Bifield, 73, of Morehead City, was traveling southbound on University Drive on a 2024 Harley Davidson when a 2024 Nissan Altima made a left turn from Larchmont Road onto University Drive.
The car struck the motorcycle, throwing Bifield off the bike.
EMS rushed Bifield to a hospital, where he later died from his injuries.
The driver of the Nissan, a 75-year-old Durham woman, was not injured.
Anyone with information on this crash is asked to contact Investigator J.T. Rose at (919) 560-4935 x29409.