It happened at Rogers Road and Fletchers Chapel Road in northern Durham.
Chopper 11 was over the scene as state troopers investigated. Damage was visible on the school bus' rear left side.
The road was closed for a short while but a lane has been reopened and cars are being directed through.
No students were injured. The motorcyclist was not at the scene. There was no word on whether the operator was injured.
This is a developing story. Check back for updates.