The agency says the person is an adult in the western part of the state and died due to complications from the flu during the first week of October.
The announcement comes as the North Carolina Health Department is releasing its latest flu data, and it shows Emergency Department visits are down half a percentage point.
Wake County is gearing up to open a walk-in flu vaccine clinic.
Starting on Thursday, October 9, Wake will begin welcoming walk-ins at its flu vaccination clinic.
The clinic will be open every Thursday from 1:00-6:00 p.m. It's located inside the Wake County Public Health Center at 10 Sunnybrook Road in Raleigh.
"We see more respiratory illnesses as it gets colder and we're headed into that season," said Wake County Director of Nursing Tina Payton.. "It gives you a chance to build your immunity before the holidays come up, and that's always a big time where people get together indoors and there's a higher opportunity for illness."
State data shows ER visits this year are trending down, and the number of visits is lower than the past two seasons after an active summer.
"(There was an) unusual surge of respiratory illnesses. Some of them were flu, some of them were COVID, even during the summer," said Payton.
In addition, Wake is also preparing to start offering COVID shots.
NCDHHS announced it would be following the CDC's updated recommendations and will allow folks to get the newest COVID-19 vaccine without a prescription.
While ABC11 News spoke with folks in Wake County who will be getting a COVID shot this year, Wilson resident Kara Wood still plans on opting out.
"Not for myself or my daughter," said Wood. "It's just something we decided not to do."