Officers responded shortly before 12:45 a.m. to a ShotSpotter alert in the 100 block of Rockefeller Court.
While officers were still there, two men arrived at UNC Health Wayne suffering from gunshot wounds.
A short time later, a third man -- also with a gunshot wound -- was reportedly taken from Greene County to ECU Health Medical Center, police said.
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The Goldsboro Police Department's Investigative Services Bureau and Crime Scene Unit were notified and responded to start a criminal investigation.
It was not immediately clear whether the shootings were connected. All three victims are from Goldsboro, police said. The victims are 21, 19, and 19 years old, police added.
There were no details about their conditions.
The investigation into this incident is ongoing.