Brandon Huntley-Hatfield scored 13 points and Ben Middlebrooks had 10 points and 10 rebounds for the Wolfpack.
It came on a night when NC State hung two new banners in the rafters at the Lenovo Center -- one for last season's ACC championship and the other for the team's run to the Final Four.
NC State led 50-35 at halftime and the Wolfpack stretched their lead to 20-plus in the first four minutes of the second half.
Except for just a few possessions, the lead was at least 20 throughout the remainder of the game.
The lead first reached 30 on a layup by Middlebrooks near the five-minute mark and peaked at 33 when Bryce Heard hit two free throws in the final minute.
The Wolfpack scored 50 points in the first half, 37 of which came in the final 12 minutes. Nine players scored with nobody reaching double figures.
Freshman Mister Dean led the Spartans with 14 points, Karmani Gregory had 13 and Nic Book added 10.
The game marked the debut of Marty Richter as head coach of SC Upstate.
NC State is hoping to continue last season's success when the Wolfpack won the ACC Tournament and reached the Final Four of the NCAA tournament. One of six ACC teams that have won a national championship, NC State beat the other five - Louisville, Syracuse, Duke, Virginia and North Carolina - to win the ACC Tournament.
The Associated Press contributed.