It happened Saturday afternoon on Piney Grove Wilbon Road near Wade Nash Road.
The State Highway Patrol says a car driven by 16-year-old Madison Pearce, of Holly Springs, crossed the center line and hit a pick-up truck head-on.
The two people in the truck were taken to Wake Med with injuries that were not life-threatening.
Investigators do not believe speed or alcohol were factors in the crash.
The investigation is ongoing.
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