It happened just before 11 a.m. on Monday at the Heritage Court Apartments at 509 E. Main St.
Clayton Police said 43-year-old Michael Corteze Sanders was charged with first-degree murder in the stabbing death of his mother, 65-year-old Robie Annette Sanders.
She was found with multiple stab wounds and pronounced dead at the scene.
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An autopsy will be performed Tuesday.
The homicide and motive remain under investigation, police said.
Anyone with information regarding this case is urged to contact the Clayton Police Department at (919) 553-4611 or the Tip Line at (919) 553-1555.