It happened shortly before 6 p.m. Tuesday in the 900 block of East Main Street, near Alston Avenue.
When police arrived, they found a man with a gunshot wound inside a Nissan Altima after it crashed into a pole.
Abdur Rasheed Ali Muslim II, 26, of Durham was pronounced dead at the scene.
Investigators said they believed Muslim may have been shot during an argument with another person. The incident did not appear to be random, according to investigators.
No charges have been filed at this time.
Anyone with information is asked to call Investigator J. Barr at (919) 560-4440, ext. 29325 or CrimeStoppers at (919) 683-1200.
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