The Highway Patrol said the first accident involving 25 vehicles happened around 5:45 p.m. in Graham. Troopers said heavy rain and fog combined with people driving too fast for the conditions contributed to causing the crash.
As emergency workers tried to clear the first crash, drivers coming in the other direction slowed down and other vehicles collided with them.
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There were a total of nine accidents, seven going west and two going east on the interstate from exits 147 and 153 in Alamance County.
The interstate finally reopened shortly before 11 p.m.