It happened at the intersection of Fayetteville Road and Purser Drive, near Walmart.
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According to the Wake County Sheriff's Office, a deputy spotted a bike traveling at a high rate of speed and attempted to pull it over, but the motorcyclist kept going.
Deputies identified the motorcyclist as Skyler Morrison of Holly Springs.
Morrison's motorcycle eventually crashed into a Garner police car, that was headed to an unrelated call.
He is expected to be charged with felony speed to elude.
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Garner police are investigating the crash.
Authorities said Morrison is currently in the hospital with a broken leg.