Isai "N" - who was wanted in the U.S. - was arrested in the border city of Nogales, Secretary Omar Harfuch, the head of Security and Citizen Protection, said in a post on X.
Separately, authorities also seized more than 1,500 pounds of cocaine and 150 firearms during the execution of a search warrant in Tapachula in the southern state of Chiapas, Harfuch announced. Authorities also seized 363 magazines and 18 grenades.
Harfuch called the operations "significant" actions against criminal organizations.
ABC News contributed to this report.