A Chevrolet work truck was reportedly broken down near Mile Marker 168 when a GMC SUV crashed into the back of it.
The driver of the GMC died, troopers said.
The driver of the Chevy work truck was taken to Duke Hospital with non-life threatening injuries.
The North Carolina Department of Transportation closed the inside lane of I-85 north while crews cleared the scene.
All lanes have since reopened, but officials said there was still congestion from the crash.
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Highway Patrol is withholding the identification of the driver killed pending next of kin notification.
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