It happened around 9:30 p.m. on Raleigh Road near where it crosses with Greenwood Road.
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According to investigators, a vehicle was driving the wrong way on Raleigh Road when another car slammed into it head-on.
The driver of one of the vehicles died at UNC Hospitals.
The other was not seriously hurt.
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Further details surrounding the incident, including the drivers' names, have not been released at this time.