It happened about 2:50 p.m. in the 100 block of Dairy Road and Barber Mill Road.
There were eight students on the bus when it collided with a 2017 Honda Accord, a Johnston County Schools spokesperson said.
One student was taken to Johnston Medical Center in Clayton for treatment of a "possible minor injury," the spokesperson said.
The other seven students and the bus driver were checked out by Johnston County EMS and released.
It wasn't immediately known whether anyone in the Honda suffered any injuries.
The school bus pulled into the parking lot of a memory-care facility after the incident. There appeared to be middle-school to high-school students on board. The bus did not appear to be significantly damaged and later drove away as police concluded that portion of the investigation.
The incident remains under investigation.