The crash happened Thursday on Interstate 40 between exits 390 and 398 in Pender County.
State troopers said 25-year-old Rebecca Claire Rains lost control of her Honda Accord, crossed the median after overcorrecting, and hit a tractor-trailer head-on.
The semi driver, a 61-year-old man from Murfreesboro, suffered minor injuries and was taken to Pender Memorial Hospital for treatment.
Heavy rain was falling at the time of the crash.
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