The deadly incident happened around 9:20 p.m. Tuesday on Bert Winston Road in Youngsville.
Sheriff Kevin White said "an elderly woman" was found dead inside the home.
An ABC11 breaking news crew at the scene reported a heavy law enforcement presence there. Authorities could be seen placing evidence markers on the road.
Investigators were also examining bullet holes in a trailer home and a shattered glass door.
Anyone with information on this case is asked to please contact the tip line at (919) 514-9577.
ABC11's Jamiese Price contributed.