It happened around 9:10 p.m. Saturday in the 2800 block of Rochelle Street. Police said the male victim, 22-year-old Usha Chatman, was found in a vehicle.
Police are still investigating and have not identified any suspects.
This is the second shooting death in Durham on Saturday. Earlier, a man died at the hospital after being shot at an apartment complex on Ivey Wood Lane.
Police have not said if the two shootings are related.
Anyone with information is asked to call Investigator J. Barr at (919) 560-4440, ext. 29325 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.