It happened just before 7:30 a.m. Friday on Reedsford Road near Melvabrook Drive, a few miles south of Clinton.
A resident's doorbell camera captured the moment a white car struck a pedestrian who was walking on the shoulder.
Troopers said a 32-year-old woman was seriously injured. She was flown to WakeMed.
The car is believed to be a 2009 to 2014 Acura TL and is likely missing the passenger-side mirror. It was last seen traveling east toward Beaman Woods Road.
Anyone with information is asked to contact the Highway Patrol.