Officers responded about noon to the 100 block of Whitley Drive.
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Police Chief Pete Hedrick told the JoCo Report that a woman was taken to WakeMed and underwent surgery. Her condition was not immediately known but police told ABC11 that there was a history of domestic-violence calls at the home.
Hedrick also said the victim and suspect knew each other and that after the shooting, the gunman got into a vehicle and left.
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There is no danger to the public, police said. The suspect is known to police.
The nearby Neuse Charter School, which is across from Smithfield-Selma High School, was briefly put on lockdown as a caution. Police told ABC11 that the lockdown was put in place so that the suspect would not try to take the victim's child.
The case remains under active investigation.