The Tar Heels were in control throughout and pulled away with less than six minutes left to play in the second half with three fast-break buckets.
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Coby White led UNC with 19 points seven rebounds and six assists. The impressive freshman point guard had just one turnover.
Dwayne Sutton had 14 points for Louisville (20-13). The Cardinals shot just 10 of 34 from 3-point range.
Senior Luke Maye also had 19 points, along with nine rebounds for the Tar Heels.
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The Tar Heels led 45-35 at halftime and never trailed in the second half.
Up next for North Carolina is the semifinal matchup on Friday against rival Duke.