It happened just before 4 a.m. where I-40 and I-85 join together.
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The North Carolina Highway Patrol said the truck driver fell asleep at the wheel.
The truck's trailer was split open when it hit a bridge support - spilling bananas all over the highway.
Several lanes of I-85 were closed while the mess is cleaned up.
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Truck carrying bananas flips on I-85
Boxes of bananas on I-85