After 11 p.m., the Cary Fire Department was called to the vape and tobacco shop in the 200 block of Meeting Street. The shop is in a small shopping center behind Lowes off Walnut Street.
When firefighters arrived, they found heavy smoke inside the store and extinguished the fire.
Both the vape shop and a nearby business Tenko Japan restaurant have smoke damage.
The cause of the fire is yet known.