Authorities in Godwin responded to the crash shortly after 7 p.m. Investigators say an SUV was driving erratically and crashed into the back of another car, causing it to go into a guardrail. It also hit a second car.
Two people were taken to the hospital with non-life-threatening injuries.
I-95 reopened at 8 p.m. when all vehicles were removed from the roadway and moved to the next exit. It was backed up nearly six miles southbound, during the closure.