The call came in at 2:15 p.m. Monday afternoon as a domestic dispute but later turned into a shooting call off Ellington Road in Manson.
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Two adults, a man and a woman, were lying on the ground and were pronounced dead at the scene.
Two children, ages 16 and 10 were rushed to hospitals with serious injuries.
Sheriff Johnny Williams says his investigators are working with the State Bureau of Investigation to determine a motive.
Williams could not say for yet how the four victims are connected but they are treating this case as a homicide right now.
"They had a relationship," Sheriff Williams said. "I would say they're not blood kin. Some of them are not blood kin. That's something we're trying to find out now."
Nearby neighbors tell ABC11 they were unaware people were living inside the house where the shooting occurred. Most believed it was unoccupied. News of what happened came as a shock.
"It's heartbreaking," said Chakita Person who lives not far from the crime scene. "Because I have kids that I have to raise too. But, it's heartbreaking for these innocent kids."
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This is a developing story, check back for details.