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It happened just after 9:30 a.m. on Main and Railroad streets in downtown Fremont.
Officials tell ABC11 that a CSX train struck the Coca-Cola truck, causing it to slam into several vehicles that were parked at a nearby cafe.
Images from Chopper 11 HD showed hundreds of soda bottles spilled out of the truck after the crash.
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No injuries were reported.
It is unknown why the truck was on the tracks when the train hit it.
Fremont is about 50 miles east of Raleigh.