The Clerks Office of Wake Superior Court said jury selection for the case began Monday.
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James Fidel Jennings is charged with killing 11-month-old Zavion Haywood in May 2012.
Zavion died in his home on Saint Giles Street near Glenwood Avenue.
Jennings was arrested in October 2017.
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According to our newsgathering partners at the News & Observer, a cousin who witnessed the incident when he was 3 years old will testify during the trial.
During the investigation, detectives said an autopsy showed that Zavion was asphyxiated while in Jennings' care.