According to a news release, at least one person in a silver sedan fired shots into an SUV just before 12:45 p.m. while both cars were driving.
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Damario Poole, 31, of Durham, died from his injuries. Deputies said a second victim was taken to a hospital in unknown condition.
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The shooting is still under investigation.
Anyone with information on the case is asked to contact Durham Police at (919) 560-7151 or Durham Crimestoppers at (919) 683-1200.