Officers said a 48-year-old man and a 29-year-old woman were shot on St. Augustine Street at East Jones Street, east of downtown, just after 9 p.m.
They both were transported to Wake Med in serious condition.
No one is in custody; the shootings remain under investigation.
Those with any information are asked to call Raleigh CrimeStoppers at (919) 834-HELP (4357) or visit raleighcrimestoppers.org for text and email reporting options.