The crash happened about 11:45 a.m. at Barefoot Road and West Academy Street/N.C. 42.
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The crash caused both vehicles to overturn, FVPD said.
One person was killed. The name of the victim has not yet been released as police work to notify next-of-kin.
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Police officers are posted and rerouting traffic as needed. Drivers are asked to avoid the area if possible.
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FVPD said it was seeking witnesses to the crash. Anyone with information is asked to please call the Fuquay-Varina Police Department at (919) 552-3191.
This is a developing story. An ABC11 Breaking News Crew is en route to the scene. Check back for updates.