The crash happened about 2 a.m. after state troopers got a call about a speeding motorcycle, then saw the bike go by.
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Troopers say the motorcycle was going more than 100 mph when it passed a trooper on U.S. 1.
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The chase started shortly after midnight, first along U.S. 1 then on I-40, heading east out of Cary.
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That's where the motorcycle hit a car and the chase ended.
One other person went to the hospital with what troopers describe as minor injuries.
No names have been released.
All lanes of I-40 have been reopened.