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The crash involved a tractor-trailer and a car.
Troopers on scene said the car was heading southbound on I-95 when it crossed the median and hit the tractor-trailer head-on in the northbound lane. The driver was taken to the hospital with serious injuries, the truck driver was not injured.
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The right lane of I-95 North was closed for hours near Parkton, four miles north of Exit 33, US-301.
The lane reopened about 5:30 p.m. but traffic remains backed up for nearly nine miles.
Stay up to date on Thursday's weather snow coverage here.