Fire crews responded around 10 a.m. to a home in the 2100 block of Wintergreen Place.
Officials confirmed the fire was fatal and said one person was pronounced dead at the scene.
Five people were inside the home when the fire broke out. Authorities have not released additional information about the victim or the conditions of the other occupants.
The cause of the fire remains under investigation.
Durham fire officials said more information is expected to be released as the investigation continues.
This is a developing story. Check back for updates.