Fire crews were dispatched around 1:37 a.m. to a home along Willow Tower Court.
It's still unclear how the fire started or exactly how many dogs were inside the home at the time.
The cause and origin of the fire remain under investigation.
According to the Durham Fire Department, crews were called around 3 a.m. to the 5000 block of Rollingwood Drive.
First responders were called to a structure fire in the 100 block of Ethans Glen Court.
Holly Springs fire officials confirmed the fire started outside the home and was accidental.