Durham police said emergency officials responded to calls about a crash on NC Highway 147 near Briggs Avenue at 12:30 p.m.
Police said a cement truck rear-ended a passenger vehicle in the northbound lanes of Highway 147.
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The driver of the passenger vehicle was taken to the hospital with life-threatening injuries.
All lanes of NC Highway 147 are open to traffic.
1 person seriously injured in crash with cement truck on Highway 147