Morrisville police said emergency responders were called to Morrisville Carpenter Road and Chapel Hill Road for a head-on collision just after 4:45 p.m.
When authorities arrived, they found a Nissan Rogue driven by 34-year-old Lauren Bradwell of Fuquay-Varina, that had collided with a semi-truck.
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Police said after an investigation, Bradwell was arrested for driving while intoxicated.
The driver of the semi-truck was taken to WakeMed to be evaluated, authorities said.