Just before midnight, first responders headed to the scene near Denim Drive and Raiford road in the Town of Erwin.
Crews say they found the passenger side of the car up-right in the yard of a home with severe damage.
A 12-year-old was taken to WakeMed in Raleigh as a trauma patient.
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First responders say a 5-year-old was evaluated and released to other family members that arrived at the scene.
The driver suffered minor injuries and was arrested at the scene, accused of driving while under the influence.
The name of the driver has not been released.